Protein Modification Reagents
Medchemexpress LLC DSPE-PEG-SH | 1462982-18-8 | 90.0% | 1,000 Da | C44H86NO10PS | 250 MG
DSPE-PEG-SH (MW 1000) is a thiol-terminated PEGylated phospholipid reagent used to introduce free thiol groups onto liposome or nanoparticle surfaces for subsequent bioconjugation. It is supplied for research use in small laboratory pack sizes and is commonly employed in formulation, surface modification, and targeted delivery workflows.
- Thiol functional group for conjugation to maleimide reagents.
- Average molecular weight of approximately 1,000 Da.
- Amphiphilic phospholipid-PEG structure for incorporation into lipid bilayers.
- Enables surface modification of liposomes and nanoparticles.
- Supplied in small research pack sizes for laboratory use.
- Typical reported purity around 90%.
Medchemexpress LLC Azido-AHPC-PEG3 (VHL ligand-linker) pyrrolidine-2-carboxamide | 1797406-80-4 | MFCD31807299 | ≥95.0% | 645.77 g/mol | C30H43N7O7S | 10 MG
(S,R,S)-AHPC-PEG3-N3 is an E3 ligase ligand-linker conjugate that couples an (S,R,S)-AHPC VHL-binding motif to a three-unit PEG linker terminated with an azide. It is intended as a click-chemistry reagent for PROTAC synthesis and bioconjugation, enabling covalent linkage to alkyne-bearing partners.
- Molecular weight 645.77 g/mol.
- Chemical formula C30H43N7O7S.
- CAS number 1797406-80-4.
- Purity ≥95%.
- Suitable for CuAAC and SPAAC click reactions.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Soluble in ethanol, water, and DMSO at concentrations commonly used for bioconjugation.
eMolecules Diketone-PEG12-DBCO | Broadpharm |1092.290 | C58H81N3O17 | 0.000 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 10mg | 462125387
Diketone-PEG12-DBCO | Broadpharm |1092.290 | C58H81N3O17 | 0.000 | CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)cc1 | 10mg | 462125387
Medchemexpress LLC (S,R,S)-AHPC-PEG2-NH2 dihydrochloride | 2341796-76-5 | 648.64 g/mol | C28H43Cl2N5O6S | 100 MG
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride is a VHL E3 ligase ligand-linker conjugate used as a building block in PROTAC synthesis. It combines an (S,R,S)-configured AHPC VHL ligand with a two-unit PEG linker terminating in a primary amine and is supplied as a dihydrochloride salt in powder form for research use.
- VHL ligand-linker conjugate for PROTAC assembly.
- Two-unit PEG linker with terminal primary amine.
- Dihydrochloride salt stable as a sealed powder.
- Supplied in small milligram quantities for medicinal chemistry workflows.
- Suitable as a synthetic building block in degrader design.
Nanocs Biotin PEG Maleimide, 100mg
Purity: >95%, Solubility: Soluble in water, Biotin PEG Maleimide is one of Nanocs pegylated Biotinylation reagents with an activated maleimide group. Maleimide is able to react with thiol/sulfhydryl groups rapidly and specifically at neutral pH. Reaction between maleimide and thiol group enables fast conjugation of biotin tag to targeted molecules or material surfaces. Resulted biotin moiety can bind to avidin or streptavidin with high affinity. PEG linker between biotin and maleimide offers better water solubility, reduced steric hydrance and enhanced stability.
Medchemexpress LLC Nh2-peg4-dota | 2090232-34-9 | 97.0% | 622.71 g/mol | C26H50N6O11 | 50mg
NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy
Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 1 ML
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. This product is for research use only and not sold to patients.
- Incorporates an (S,R,S)-AHPC-based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Induces ubiquitination and subsequent proteasomal degradation of target proteins
Medchemexpress LLC Tos-PEG4-NH-Boc (PROTAC Linker 7) | 1246999-33-6 | >98.0% | 100 MG
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker.
- Used in the synthesis of PROTACs.
- Connects two different ligands.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC DSPE-PEG-COOH | No CAS number listed for this product (HY-W591461). | No MFCD number listed for this product (HY-W591461). | 100.0% | 2000 (average) | No chemical formula listed for this product (polymeric PEG; variable repeat unit). | 25 MG
DSPE-PEG-COOH, MW 2000 is a PEGylated phospholipid used to formulate liposomes and lipid nanoparticles. It is supplied as a white to off-white solid and features a terminal carboxylic acid that can be activated to form stable amide bonds with primary amines for surface conjugation. Typical storage is -20°C, sealed, away from moisture.
- Terminal carboxylic acid for amide bond conjugation.
- Suitable for liposome and lipid nanoparticle formulation.
- White to off-white solid for easy handling and weighing.
- Available in small research pack sizes for lab use.
- High purity suitable for research use (purity ≥99.9%).
Cayman Chemical kb NB 142-70 25mg
A selective PKD inhibitor (IC50s = 28.3, 58.7, and 53.2 nM for PKD1, 2, and 3, respectively); inhibits prostate cancer cell migration and invasion, as well as reduces wound healing in vitro.
AdipoGen Collagen Chromo-Substr Comp A
Chemical. CAS 118081-33-7. Formula C38H52N10O8 . 2H2O. MW 812.91. Synthetic. Enzyme substrate.
ABclonal Technology SF3B6 Rabbit pAb
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.
Revvity Health Sciences Inc IVISense Neutrophil Elastase 680 FAST Fluorescent Probe
IVISense Neutrophil Elastase 680 FAST Fluorescent Probe